The arrival from Tegel airport was easy (first bus 128 to Kurt-Schumacher-Platz and then U6 line to U Naturkundemuseum, which is a subway stop near the hotel). The hotel staff was super friendly and helpful in every matter, big thumbs up! The hotel and the (smallish) room was quiet and clean (other than the wall-to-wall carpet which looked a bit sketchy and, in general, I prefer parqueted floors, anyway). If you do not wish your room cleaned the next day, you can mention it at the reception and get a drink voucher at the hotel bar, which is nice.
There are some cafes and restaurants nearby to have e.g. breakfast if hotel breakfasts are not your thing. Getting to other parts of Berlin is easy by the subway but you may have to change lines more than once. It might be worth to check out also the tram and bus lines near the hotel since a walk to e.g. Rosenthaler Platz takes roughly 20mins and the subway ride with line changes is no quicker.